Scottish Collie Club takes a keen interest in canine health matters and regularly provides topics of interest and updates to exhibitors and breeders.

The Kennel Club maintains a database of recognised health test results for all breeds, which includes clinical eye results and Hip and Elbow Assessments under the KC/BVA Scheme, in addition to DNA test results for a variety of inherited conditions.

The East Anglian Collie Association (EACA) has established a Health Register which includes KC/BVA Hip and Elbow assessments, clinical eye test results, DNA (genetic) test results for MDR1, CEA/CH, PRArcd2 (the early onset form of PRA) and DM etc. A DNA test provides a more accurate result than the subjective CEA clinical test, which often proves inaccurate.

In addition to the Health Register, EACA is also setting up a CEA database for genetically tested Rough Collies and this can now be found on-line at:

http://e-a-c-a.co.uk/DNAtests.html  (link in right hand panel)

For anyone wishing to have any of their dogs added Pat Hutchinson, Health co ordinator for EACA would love to hear from you with details.

Cathy Proctor May 2015

 

Many herding breed dogs (the most commonly affected in the UK are: All breeds of Collie, Shetland Sheepdog, GSD and, Australian Shepherd dogs - including cross breeds) have a genetic predisposition to adverse drug reactions involving over a dozen different drugs.

The most serious adverse drug reactions involve several antiparasitic agents, Ivermectin, Milbemycin (and related drugs), the antidiarrheal agent Loperamide (Imodium), and several anticancer drugs (Vincristine, and Doxorubicin, plus several others). These drug sensitivities result from a mutation in the multidrug resistance gene (MDR1 gene).

 

LIST OF DRUGS THAT CAUSE SENSITIVITY TO DOGS WITH MDR1 MUTATION

Class A DO NOT use these drugs in dogs with the MDR1 Gene Defect

Ivermectine substances "Anti parasites": (Diapec®, Ecomectin®, Equimax®, Eqvalan®, Ivomec®, Noromectin®, Paramectin®, Qualimec®, Sumex®, Virbamec®) 

Doramectine substances "Anti parasites":  (Dectomax® )

Loperamide substances "ant diarrheal ": (Imodium®)

Moxidectine substances "Anti Parasites" (Cydectin®, Equest®) 

(Flagyl )

Class B

Use only under close control of veterinarian

Cytostatics  "Chemotherapy": (Vinblastine, Vincristine, Doxorubicine, Paclitaxel, Docetaxel, Methotrexat, Vincristine)

Immunosuppressive: (Cyclosporine A)

Heart glycosides: (Digoxine, Methyldigoxine)

Opioids: (Morphium)

Antiarrhythmics: (Verapamil, Diltiazem, Chinidine)

Antiemetics (Ondansetron, Domperidon, Metoclopramide )

Antibiotics (Sparfloxacin, Grepafloxacin, Erythromycin)

Antihistamin (Ebastin)

Glucocorticoid (Dexamethason)

Acepromazine (tranquilizer and pre-anesthetic agent) *

Butorphanol "analgesic and pre-anesthetic agent" *

Other drugs: Etoposide, Mitoxantrone, Ondansetron, Paclitaxel, Rifampicin 

Class C Can be used only in the permitted application form and dose Selamectin (Stronghold®), Milbemax®  and Advocate® .